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. 2021 Jun 11;8:689799. doi: 10.3389/fmolb.2021.689799

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Copyright © 2021 Apaolaza, Petropoulou and Rodriguez-Calvo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of the prohormone processing enzymes PC1/3, CPE and PC2 in the endocrine pancreas. (A) Representative images showing the distribution and localization of the proinsulin processing enzymes PC1/3 (slide #3, upper row), CPE (slide #4, middle row) and PC2 (slide #5, lower row) in the islets. (B) Violin plots showing the proportion of PC1/3+, PC2+, and CPE+ cells in beta (green) and alpha cells (violet). Each dot represents an islet. Scale bar: 100 μm.