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. 2021 Jun 11;8:689799. doi: 10.3389/fmolb.2021.689799

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Copyright © 2021 Apaolaza, Petropoulou and Rodriguez-Calvo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of the proportion and density of immune infiltration in the exocrine and endocrine pancreas. (A) Representative images of slide #1 showing CD45⁺ cells in the vicinity of an insulin-containing islet (upper row) and representative images of slide #6 showing CD3+ (lower row left) and CD8+ (lower row middle) cells close to a chromogranin A positive (CHGA+) islet. (B) Bar graphs show the proportion of infiltrated islets by CD3+, CD8+, CD4+, and CD45+ positive cells expressed as percentage of total islets. (C) Bar graphs show the density of CD3+, CD8+, CD4+, and CD45+ cells expressed as number of cells per islet area (mm²). Scale bar: 50 μm.