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. 2021 Jun 11;9:690522. doi: 10.3389/fcell.2021.690522

FIGURE 3.

FIGURE 3

Downstream targets of XIST in colon cancer cells (Chen et al., 2017; Song et al., 2017; Xiao et al., 2017; Liu et al., 2020; Sun et al., 2018; Liu et al., 2019; Wang et al., 2020b). XIST enhances proliferation and epithelial–mesenchymal transition of colon cancer cells via sequestering miR-486-5p and increasing expression neuropilin-2 (Liu et al., 2019). It can also sequester miR-137 and subsequently increase expression of EZH2 to enhance metastatic ability of colon cancer cells (Liu et al., 2018).