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Origin of macrophages in PDAC. Macrophages in PDAC are derived from a mixed population of tissue-resident cells and circulating monocytes. HSC/monocyte-derived macrophages play a key role in regulating immune suppression and adaptive immunity, while embryonically-derived macrophages are important in promoting fibrosis and extracellular matrix remodeling in PDAC. Figure created in Biorender.
