Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 8;13(12):2860. doi: 10.3390/cancers13122860

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Strategies to therapeutically target TAMs in PDAC. Major TAM-targeting strategies in PDAC include (1) TAM depletion by blocking CSF1R signaling; (2) inhibition of TAM recruitment by blocking CCL2/CCR2 signaling; (3) suppressing the pro-tumorigenic activity of AAMs by inhibiting PI3Kγ, CD11b, IRF4 or TIE2; and (4) reprogramming TAMs towards a tumoricidal classically-activated endotype via CD40 agonists or inhibition of the ‘do not eat me’ CD47/SIRPα signaling axis to promote tumor cell phagocytosis. Figure created in Biorender.