Table 1.
Demographics, risk factors, and outcomes of patients with thrombotic microangiopathy (TMA).
| Variable | Overall | No TMA | TMA | p | |
|---|---|---|---|---|---|
| 12,369 | 12,276 | 93 | |||
| Age | 0–1 years | 1948 (15.7) | 1939 (99.5) | 9 (0.5) | 0.109 |
| 2–4 years | 2819 (22.8) | 2793 (99.1) | 26 (0.9) | ||
| 5–9 years | 2775 (22.4) | 2758 (99.4) | 17 (0.6) | ||
| 10–14 years | 2339 (18.9) | 2314 (98.9) | 25 (1.1) | ||
| ≥15 years | 2488 (20.1) | 2472 (99.4) | 16 (0.6) | ||
| Sex | Male | 7239 (58.5) | 7187 (99.3) | 52 (0.7) | 0.608 |
| Female | 5130 (41.5) | 5089 (99.2) | 41 (0.8) | ||
| Race | Non-Hispanic White | 6974 (56.4) | 6914 (99.1) | 60 (0.9) | 0.265 |
| Non-Hispanic Black | 1450 (11.7) | 1445 (99.7) | 5 (0.3) | ||
| Hispanic | 2304 (18.6) | 2290 (99.4) | 14 (0.6) | ||
| Asian | 432 (3.5) | 428 (99.1) | 4 (0.9) | ||
| Other | 1209 (9.8) | 1199 (99.2) | 10 (0.8) | ||
| Other | 7560 (61.1) | 7494 (99.1) | 66 (0.9) | ||
| HSCT Type | Autologous | 4043 (32.7) | 4031 (32.8) | 12 (12.9) | <0.001 |
| Allogeneic | 8177 (66.1) | 8099 (66) | 78 (83.9) | ||
| Not specified | 149 (1.2) | 146 (1.2) | 3 (3.2) | ||
| Allo Source | Bone Marrow | 3517 (43) | 3492 (43.1) | 25 (32.1) | 0.045 |
| Peripheral blood | 3195 (39) | 3154 (38.9) | 41 (52.6) | ||
| Cord blood | 1475 (18) | 1463 (18) | 12 (15.4) | ||
| CMV | 958 (7.7) | 940 (7.7) | 18 (19.4) | <0.001 | |
| HHV6 | 138 (1.1) | 130 (1.1) | 8 (8.6) | <0.001 | |
| Fungal infection | 835 (6.8) | 814 (6.6) | 21 (22.6) | <0.001 | |
| GVHD | 1471 (11.9) | 1443 (11.8) | 28 (30.1) | <0.001 | |
| VOD | 227 (1.8) | 222 (1.8) | 5 (5.4) | 0.011 | |
| Hypertension | 3288 (26.6) | 3226 (26.3) | 62 (66.7) | <0.001 | |
| Renal failure | 1280 (10.3) | 1232 (10) | 48 (51.6) | <0.001 | |
| Plasmapheresis | 119 (1) | 91 (0.7) | 28 (30.1) | <0.001 | |
| Hemodialysis | 385 (3.1) | 363 (3) | 22 (23.7) | <0.001 | |
| Died | 1531 (12.4) | 1503 (12.2) | 28 (30.1) | <0.001 | |