Table 2.
Charcteristics of CD patients classified as Paneth cell abnormal mitochondria phenotype.
| Characteristic | Normal Mitochondria | Abnormal Mitochondria | p-Value Normal vs. Abnormal Mitochondria |
|---|---|---|---|
| Number of patients | 19 | 11 | |
| Gender, n (%) | |||
| Male | 14 (74) | 6 (54) | 0.24 |
| Female | 5 (26) | 5 (46) | |
| Age, n (%) | |||
| <40 | 8 (42) | 3 (27) | 0.47 |
| <50 | 10 (53) | 6 (54) | 0.99 |
| <60 | 14 (74) | 8 (72) | 0.99 |
| Race, n (%) | |||
| Caucasian | 16 (84) | 8 (72) | 0.64 |
| African American | 2 (11) | 1 (9) | 0.99 |
| Asian | 0 | 1 (9) | 0.37 |
| Hispanic | 1 (5) | 1 (9) | 0.99 |
| Harvey Bradshaw Index Score, n (%) | |||
| <5 | 11 (58) | 9 (82) | 0.25 |
| 5 to 7 | 5 (26) | 2 (18) | 0.99 |
| 8 to 16 | 1 (5) | 0 | 0.99 |
| >16 | 1 (5) | 0 | 0.99 |
| Endoscopically active disease present, n (%) | 11 (58) | 5 (46) | 0.71 |
| IBD treatment at biopsy, n (%) | |||
| 5-ASA | 3 (16) | 2 (18) | 0.99 |
| 6MP/AZA/MTX | 4 (21) | 2 (18) | 0.99 |
| Biologics | 10 (53) | 7 (64) | 0.71 |
| Steroids | 2 (11) | 4 (36) | 0.16 |
| NSAIDS | 1 (5) | 3 (27) | 0.13 |
| No treatment | 3 (16) | 2 (18) | 0.99 |
| Smoking, n (%) | 1 (5) | 2 (18) | 0.54 |
| Type I Paneth cell phenotype, n (%) | 1 (5) | 9 (82) | <0.0001 |
| Other conditions, n (%) a | |||
| Diabetes mellitus | 1 (5) | 3 (27) | 0.13 |
| Hypertension | 4 (21) | 5 (46) | 0.23 |
| Cerebrovascular event | 1 (5) | 2 (18) | 0.54 |
| Ankylosing spondylitis | 2 (11) | 2 (18) | 0.61 |
a Too few patients for analysis for conditions not listed.