Table 2.

Oxidative stress in POAG—human studies.

Study	Finding
Ferreira et al. 2004 [44]	Reduced levels of water–soluble antioxidants (glutathione, ascorbate, tyrosine) in aqueous humour of POAG compared to controls
Izzotti et al. 2003; Saccà et al. 2005 [45,46]	Oxidative DNA damage is exaggerated in the trabecular meshwork of POAG patients
Gherghel et al. 2005 [47]	Glaucoma patients have lower serum GSH and total glutathoine (t–GSH) levels as compared with age–matched controls
Yildirim et al. 2005 [48]	Malonyldialdehyde (marker of oxidative stress) levels were more than 2–fold greater in the serum of POAG patients as compared with healthy controls
Tanito et al. 2012 [49]	Biological antioxidant potential level, a measure of total antioxidative stress activity, was lower in plasma in the POAG and pseudo–exfoliation syndrome groups compared with the control groups
Sorkhabi et al. 2011 [50]	Increased oxidative DNA damage in the serum and aqueous humour of glaucoma patients
Yuki et al. 2010 [51]	Increased serum total antioxidant and decreased 8–hydroxy–2′–deoxyguanosine in response to increased systemic oxidative stress in patients with normal–tension glaucoma