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. 2021 May 31;13(6):1037. doi: 10.3390/v13061037

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Potential Fc-FcγR interactions for enhanced protection with mAb administration. (1) Opsonization of viral-antibody immune complexes and clearance by phagocytic cells. (2) Altered activation and pro-inflammatory response from phagocytic cell. (3) Secretion of chemokines and cytokines to promote cellular recruitment and modify inflammation. (4) Clearance of infected cells through antibody-dependent cellular phagocytosis (ADCP) by phagocytic cells. (5) Removal of infected cells through antibody-dependent cellular cytotoxicity (ADCC) by effector cells. (6) Enhanced T cell activation through Fc-FcγR mediated DC maturation. Created with BioRender.com.