Table 1.
Summary of signaling function, mouse and human IgG interactions, and cell type expression of mouse FcγRs.
| Mouse FcγR | Function | Mouse IgG Interactions |
Human IgG Interactions |
Cellular Expression in Mice |
|---|---|---|---|---|
| FcγRI | Activation | IgG2a/c IgG2b IgG3 # |
IgG1 IgG3 IgG4 |
dendritic cells macrophages monocytes |
| FcγRIIb | Inhibition | IgG1 IgG2b IgG2a/c |
IgG1 IgG2 IgG3 IgG4 |
neutrophils B cells dendritic cells macrophages monocytes |
| FcγRIII | Activation | IgG1 IgG2a/c IgG2b |
IgG1 IgG2 IgG3 IgG4 |
NK cells neutrophils dendritic cells macrophages monocytes |
| FcγRIV | Activation | IgG2a/c IgG2b |
IgG1 IgG3 IgG4 * |
neutrophils dendritic cells macrophages monocytes |
# Debated. * Weak binding.