Skip to main content
. 2021 May 29;14(6):522. doi: 10.3390/ph14060522

Figure 2.

Figure 2

Effects of LPS and AUY-922 on IL-1β, IL6, MCP-1, TNFα and APE1/Ref1 expression in mouse lungs. Western blot analysis of IL-1β and β-actin (A), IL6 and β-actin (B), MCP-1 and β-actin (C), TNFα and β-actin (D), APE1/Ref1 and β-actin (E) expression in lungs retrieved from mice 72 h after intratracheal injection of either vehicle (saline) or LPS (1.6 mg/kg) and post-treated (24 h after LPS) with an intraperitoneal injection of either AUY-922 (10 mg/kg each, dissolved in 10% DMSO) or vehicle (10% DMSO in saline). The signal intensity of protein bands was analyzed by densitometry. Protein levels were normalized to β-actin. * p < 0.05, ** p < 0.01 vs. vehicle (VEH) and $ p < 0.05, $$ p < 0.01 vs. LPS, n = 3 animals per group. Means ± SEM.—indicates the absence, and + indicates the presence of the corresponding reagent in the treatments.