Table 1.
IC50 values of the complexes determined on chemo-sensitive (Colo 205), multidrug resistant (Colo 320) human colonic adenocarcinoma cell lines and normal human embryonal lung fibroblast cells (MRC-5) (72 h), in addition to selectivity indexes (S.I., ratio of the indicated IC50 values).
| IC50 (μM) | S.I. | ||||
|---|---|---|---|---|---|
| Colo 205 | Colo 320 | MRC-5 | MRC-5/Colo 205 | MRC-5/Colo 320 | |
| 1 | 14.04 ± 0.62 | 3.3 ± 1.3 | 2.17 ± 0.22 | 0.15 | 0.66 |
| 2 | >100 | >100 | >100 | – | – |
| 3 | 17.3 ± 3.1 | 10.7 ±1.5 | 7.6 ± 1.6 | 0.44 | 0.71 |
| 4 | >100 | >100 | 81.0 ± 6.2 | <0.81 | <0.81 |
| 5 | 21.0 ± 2.4 | 13.74 ± 0.85 | 2.95 ± 0.71 | 0.14 | 0.21 |
| 6 | >100 | >100 | >100 | – | – |
| 7 | 52.4 ± 2.7 | 29.1 ± 2.0 | 26.5 ± 3.2 | 0.51 | 0.91 |
| 8 | 80.6 ± 1.1 | 47.8 ± 7.3 | 17.6 ± 1.5 | 0.22 | 0.37 |
| RAPTA-C | >100 | >100 | >100 | – | – |
| cisplatin | 29.8 ± 1.2 | 5.58 ± 0.70 | 0.88 ± 0.09 | 0.03 | 0.16 |