Table 6.
Performance of miR-126-3p and HbA1c in predicting dysglycaemia.
| Performance Measure | Dysglycemia | Prediabetes | Diabetes | |||
|---|---|---|---|---|---|---|
| miR-126-3p | HbA1c | miR-126-3p | HbA1c | miR-126-3p | HbA1c | |
| AUC | 0.743 (0.705–0.781) |
0.753 (0.717–0.788) |
0.784 (0.742–0.827) |
0.695 (0.652–0.739) |
0.646 (0.576–0.717) |
0.861 (0.812–0.909) |
| Threshold | 1.41 (1.25–1.84) |
5.95 (5.75–6.05) |
1.78 (1.38–3.07) |
5.75 (5.75–9.95) |
1.31 (0.60–1.42) |
6.05 (6.05–6.45) |
| Sensitivity | 0.628 (0.570–0.683) |
0.591 (0.497–0.733) |
0.616 (0.545–0.683) |
0.598 (0.461–0.721) |
0.556 (0.447–0.660) |
0.761 (0.611–0.859) |
| Specificity | 0.737 (0.708–0.765) |
0.824 (0.670–0.893) |
0.804 (0.777–0.828) |
0.707 (0.643–0.846) |
0.708 (0.678–0.737) |
0.837 (0.807–0.959) |
| PPV | 0.424 (0.391–0.458) |
0.519 (0.410–0.616) |
0.401 (0.361–0.442) |
0.335 (0.234–0.430) |
0.152 (0.127–0.182) |
0.284 (0.239–0.566) |
| NPV | 0.866 (0.847–0.882) |
0.865 (0.846–0.891) |
0.907 (0.892–0.921) |
0.894 (0.875–0.916) |
0.944 (0.930–0.955) |
0.978 (0.968–0.986) |
| Accuracy | 0.718 (0.686–0.737) |
0.771 (0.685–0.810) |
0.760 (0.734–0.784) |
0.702 (0.647–0.789) |
0.684 (0.655–0.711) |
0.833 (0.805–0.938) |
| p-value for AUC Comparison | 0.281 | 0.048 | <0.001 | |||
AUC, area under the receiver operating characteristic curve; PPV, positive predictive value; NPV, negative predictive value.