Table 2.

Characteristics of publications on topics that were not found in the database during the literature review.

n	Type of Study	Intervention/Measurement/Methods	Duration	Effect	Year [Reference]
				Carbohydrates
12	randomised, controlled trial	low glycaemic load diet (LGL) or high glycaemic load diet (HGL)	12 weeks	-changes in the homeostasis model assessment of insulin resistance (HOMA-IR): −0.57 for LGL vs. 0.14 for HGL -changes in sex hormone binding globulin (SHBG): SHBG levels decreased significantly from baseline in the HGL group -changes in binding proteins (IGFBP-I and IGFBP-3): IGFBP-I and IGFBP-3 levels increased in the LGL group	2008 [20]
				Proteins
47,355	prospective cohort study	assessment of the association of milk consumption with the occurrence of AV	questionnaires on high school diet	a positive relationship between the consumption of whole and skimmed milk and the incidence of AV	2005 [21]
6094	prospective cohort study	association of correlation between drinking milk and AV	nd	-positive association between the intake of milk and AV	2006 [22]
114	case-control study	intake assessment–food intake questionnaire n = 57 patients n = 57 control group	nd	-milk and chocolate consumption were significantly higher in patients with AV	2018 [23]
106	case-control study	dietary intake of milk and dairy products along with carbohydrate/ fat/protein ratios n = 53 patients n = 53 control group	3 day (2 weekdays and 1 weekend day) consumption record	-statistically higher consumption of cheese in people with AV	2019 [24]
5	case report	developing AV after the consumption of whey protein	5.6 ± 1.8 months	-milk and dairy products were enhancers of insulin/insulin-like growth factor 1 signalling and AV aggravation	2012 [25]
				Vitamins
200	prospective, randomised, controlled and open label trial	investigated the serum level of 25-hydroxy vitamin D in AV patients and assessment of the efficacy and safety of active vitamin D in management of AV n = 100 patients n = 100 control group	3 months	-serum levels of 25-hydroxy-vitamin D were lower in AV patients than in healthy controls -AV patients were more likely to have a vitamin D deficiency than healthy people	2020 [26]
48	randomised, double-blind, placebo-controlled study	determination of the safety, tolerability and effectiveness of daily administration of an orally administered pantothenic acid-based dietary supplement in men and women with facial AV lesions n = 23 patients, n = 25 placebo group	12 weeks	-reduction in total lesion count in the pantothenic acid group versus placebo -reduction in inflammatory lesions was significantly reduced -dermatology life quality index (DLQI) values were lower at week 12 in the pantothenic acid group versus placebo	2014 [27]
				Vitamins and Minerals
150	observational study	evaluation of plasma levels of vitamin A, E and zinc in AV patients in relation to the severity of the disease n = 94 patients n = 56 control group	nd	-levels of vitamin E, vitamin A and zinc were lower among patients than in the control group -no statistically significant difference for plasma vitamin A levels between group 1 and 2 -vitamin E and zinc levels were significantly lower in group 2 than group 1	2014 [28]
				Minerals
56	randomised prospective clinical trial	group 1 (n = 14): silymarin (3 × 70 mg/day) group 2 (n = 14): N-acetylcysteine (2 × 600 mg/day)	8 weeks	-silymarin, N-acetylcysteine and selenium with AV significantly reduced serum MDA, IL-8 levels and the number of inflammatory lesions	2012 [29]
		group 3 (n = 14): selenium (2 × 100 µg/day)
				Probiotics and Prebiotics
33	pre-experimental clinical study	probiotics	30 days	-oral probiotic trigger elevated IL-10 serum levels of AV	2019 [30]
12	proof-of-concept pilot study	FOS (fructo-oligosaccharides) and GOS (galactooligosaccharodes	3 months	-FOS/GOS supplementation in people with baseline insulin levels > 6 µUI/mL (n = 6) caused a significant reduction (from 7.8 to 4.3 µUI/mL) -concentration of C-peptide decreased from 2.1 to 1.6 ng/mL	2018 [31]
				Other Factors
8197	epidemiologic investigation	association of soft drink consumption and intake of sugar from these drinks with prevalence of AV in adolescents	nd	-daily soft drink consumption increased the risk of moderate to severe AV in adolescents, mainly when sugar intake from this drink exceeded 100 g per day	2019 [32]
400	case controlled study	relationship between dietary intake of salty and spicy foods and the onset, severity and duration of AV n = 200 patients, n = 200 control group	24 h questionnaire	-patients with AV consumed higher daily amounts of sodium chloride (NaCl) than the control group -a negative correlation between the amount of NaCl in the diet of patients with AV was found -neither salty nor spicy food correlated with duration or severity of the disease	2016 [33]
80	randomised, double-blind, placebo-controlled clinical trial	-effects of a decaffeinated green tea extract (GTE) upon women with post-adolescent AV -receiving 1500 mg per day of decaffeinated GTE or cellulose for placebo group for 4 weeks n = 40–GTE group n = 40–placebo group	4 weeks	-statistically significant differences in inflammatory lesion counts distributed on the nose, periorally, and on the chin between the two groups -no significant differences between groups for total lesion counts -significant reductions in inflammatory lesions distributed on the forehead and cheek, and significant reductions in total lesion counts noticed in the GTE group -significant reductions in total cholesterol levels within the GTE group	2016 [34]

nd—no data.