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. 2021 May 31;11(6):820. doi: 10.3390/biom11060820

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Morphological characterization of C-terminally truncated RT-QuIC end products by TEM. (a) Representative TEM images of RT-QuIC end products with the samples derived from PD and DLB temporal and frontal cortices. (b) Area of aggregated fibrils and (c) length of fibrils in each aggregate structure were calculated from the TEM images of the RT-QuIC end products using ImageJ; 5 to 10 fibrils per aggregate structure were measured to calculate the average fibril length per aggregate. Bar graphs show the average +SEM (n = 3 biological replicates (cases) per condition, except for PD TBS Frontal 1-115 where n = 2 cases). One-way ANOVA with Tukey’s multiple comparison testing (GraphPad Prism) was used for statistical comparisons; * p < 0.05, ** p < 0.01. The dotted lines in panels B and C show the average fibril area and fibril length from the temporal cortex samples, respectively.