Table 4.

The dependency on oncological and demographical parameters of biomarkers concentrations represented as effect sizes and p values.

Parameter	CEA Effect Size (p-Value)	CEACAM6 Effect Size (p-Value)	Ca19-9 Effect Size (p-Value)
Demographical
Gender	0.01 (0.1) **	−0.01 (0.8) **	0.00 (0.3) **
Age	0.04 (0.46) *	0.09 (0.13) *	−0.05 (0.42) *
Diabetes mellitus	0.01 (0.1) **	0.01 (0.06) **	0.00 (0.9) **
BMI	−0.04 (0.47) *	0.01 (0.85) *	0.04 (0.51) *
Oncological
T 1	0.05 (0.001) **	0.04 (0.008) **	0.05 (0.001) **
N 2	−0.01 (0.9) **	0.00 (0.5) **	0.05 (0.002) **
M 3	0.07 (0.00005) **	0.02 (0.03) **	0.03 (0.004) **
G 4	−0.01 (0.9) **	0.00 (0.6) **	−0.01 (0.7) **
R 5	0.00 (0.5) **	0.00 (0.3) **	0.01 (0.1) **
Stage	0.06 (0.002) **	0.00 (0.3) **	0.04 (0.01) **
LNR 6	−0.05 (0.59) *	−0.05 (0.56) *	0.13 (0.14) *
Perineural invasion	0.10 (0.000004) **	0.05 (0.0008) **	0.03 (0.02) **
Perivascular invasion	0.09 (0.000007) **	0.06 (0.0005) **	0.02 (0.02) **
Tumour diameter	0.1 (0.1) *	0.1 (0.09) *	0.2 (0.00) *
Tumour localization	0.00 (0.3) **	−0.02 (0.9) **	0.00 (0.4) **
Bilirubin concentration	0.05 (0.4) *	0.01 (0.83) *	−0.04 (0.46) *

* Kendall correlation coefficient; ** eta², based on the H-statistic effect size; ¹ primary tumour; ² regional lymph nodes; ³ distant metastasis; ⁴ differentiation; ⁵ resection status; ⁶ lymph node ratio.