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. 2021 Jun 9;9(6):698. doi: 10.3390/healthcare9060698

Table 1.

Relevant studies for musical therapy.

Alternative
Therapy
Diseases or Neurological Disorder Effects on Patients Effects on Caregivers Reference
Group music program Mild-moderate dementia Increased verbalization behavior
No significant effect on agitation and anxiety
N/A Cooke M.L., 2010 [17]
Music or conversation interventions Dementia Improvement in speech content and fluency after music sessions N/A Brotons M, 2000 [18]
Reminiscence therapy (including music) Dementia
Alzheimer’s disease
Evaluation of ADAS-Cog, CSDD, NPI, Barthel Index N/A Li, M., 2017 [19]
Home therapeutic recreation intervention Dementia
Agitation
Passive behavior
Reduced disturbing behaviors Respite period
communication, emotional support
Fitzsimmons, S.; Buettner, L.L., 2002 [20]
Calming music, hand massage Dementia Reduced agitation N/A Remington, R., 2002 [21]
Music-based exercises Moderate or severe dementia Improvement in cognition N/A Van de Winckel A., 2004 [22]
Group music with movement intervention Dementia Decreased in agitated behaviours N/A Sung, H., 2006 [23]
Recreational activities (including musical therapy) Dementia Icreased mood and level of consciousness N/A Schreiner, A.S., 2005 [24]
Musical therapy Moderate or severe Alzheimer’s disease Reduced agitation and anxiety N/A Svansdottir HB, Snaedal J., 2006 [25]
Music therapy Dementia
Depression
Cortisol Levels
Reduced depression
Improved shot-term recall function
N/A Chu H., 2014 [30]
Musical therapy Dementia Cognition, psychiatric symptoms,
Daily activities
N/A Lyu J., 2018 [31]
Music therapy Dementia Decreased agitation disruptiveness and psychotopic medication N/A Ridder H.M., 2013 [32]
Music therapy
Recreational activities
Dementia Short-term decrease in agitation N/A Vink A.C., 2012 [33]
Music therapy (ML)
Kirtan Kriya meditation (KK)
Dementia
Cognitive decline
Telomere length (TL), telomerase activity (TA), and plasma amyloid-β (Aβ) levels
KK group increases Aβ40, improvement in cognitive and psychosocial status, improvements in stress, mood, QOL N/A Innes K.E., 2018 [40]
Music-based therapeutic interventions Dementia Low improvement in depressive symptoms, QOL
No improvement in agitation or behavioral disorder
N/A van der Steen J.T., 2017 [41]

N/A: not available; ADAS-Cog: The Alzheimer’s Disease Assessment Scale–Cognitive Subscale; SDD: Cornell Scale for Depression in Dementia; NPI: neuropsychiatric inventory; KK: Kirtan Kriya meditation; Aβ40: plasma amyloid-β40; QOL: Quality of life