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. 2021 Jun 4;13(6):1070. doi: 10.3390/v13061070

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cytopathic effect and replication of Bovine coronavirus (BCoV) isolate ISR2182. (A) Uninfected HRT-18G cells show intact monolayer, while cells infected with local isolate ISR2182 (1:10) for 72 h show significant changes in monolayer (white arrows). (B) Replication of BCoV ISR2182 in HRT-18G, cells were infected with isolate ISR2182 and collected at different time points. BCoV replication was measured by RT-qPCR. (C) Immunofluorescence images showing replication of BCoV isolate ISR2182 in HRT-18G cells as detected by monoclonal antibody-targeting coronavirus nucleocapsid protein, with DAPI for nucleus staining.