Table 1.

Advantages and disadvantages of major viral vectors for DNA vaccine delivery.

Sl.no	Virus	Advantages	Disadvantages	Reference
1.	Lentivirus	Can infect non-dividing cells, long-term gene expression, and can generate high immunogenicity	Chance of generation of replication-competent virus and potential for tumorigenesis	[26,27]
2	Adenovirus	Safety and high titer production	Pre-existing immunity	[28]
3	Adeno-associated virus	Long-term gene expression, non-pathogenic virus, and induces a unique CTL response	Low titer production and pre-existing immunity	[29]
4	Retrovirus	Long-term gene expression	Chance of generation of replication-competent virus, potential for tumorigenesis, and infects dividing cells only	[30]
5	Vaccinia virus	Safety, high titer production, and can generate high immunogenicity	Pre-existing immunity	[31]
6	Cytomegalovirus	Protects against SIV infection	Risk of pathogenesis in specific individuals	[32]
7	Sendai virus	Can generate high immunogenicity	Pre-existing immunity	[33]