Table 1.

Associated functions in the t-rRPE and rRPE.

t-rRPE	rRPE
Reduced basement membrane synthesis COL6A3, COL4A1, LAMA2	Reduced basement membrane synthesis COL6A3, COL4A1, LAMA2
Reduction in EMT machinery SNAI1, E2F1, TGFBR2, TGFB3	Activation of EMT machinery SNAI1, E2F1, TGFBR2, TGFB3
Transient reprogramming ASCL1	Retinal progenitor profile VSX2, ASCL1, SIX6
Suppression of proliferation MCM2/4/5/10, CDK6	Production of secreted factors PDGFD, CXCL14, WNT6, NGF, HGF
Injury and damage-response CRYAA, CRYAB, CRYBA2, GADD45G	ECM remodeling ADAMTS9, MMP9, LOXL2, PLOD1
---	MAPK transcript profile SPRY1/2, DUSP1/7
---	AP-1 transcription factor expression FOS, JUN, ATF3, MAFA