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. 2021 May 30;13(6):1867. doi: 10.3390/nu13061867

Table 1.

Dietary phytochemicals known to modulate the levels of Zn.

Dietary Phytochemicals Effect on Zn signaling References
Green tea, red wine and grape juice

  • Increase Zn uptake

  • Increase metallothioneins

 [77]
Soybean extracts and soyasaponin Bb

  • Increase ZIP4 importer

  • Increase cellular zinc levels

 [84]
Resveratrol

  • Increase total cellular Zn levels

  • Upregulate metallothioneins

  • Form Zn complexes

 [85,86,87]
Quercetin

  • Increase Zn uptake

  • Form Zn-polyphenol chelation complex

 [77,88]
Epigallocatechin-3-gallate (EGCG)

  • Increase accumulation of Zn

  • Inhibit metallothioneins and ZnT1

  • Enhance ZIP1 and ZIP4

 [89,90]
Grape-seed procyanidin extract (GSPE)

  • Inhibit ZIP3, ZIP5, ZIP7, and ZIP11

  • Enhance ZIP6, ZIP10, and ZIP13

 [90]
Curcumin

  • Improve Zn’s mobilization

  • Increase Zn-binding ligands

 [91]
Phytate

  • Inhibit the absorption of Zn

  • Form insoluble complexes with Zn

 [92,93]