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. 2021 May 30;19(6):318. doi: 10.3390/md19060318

Figure 3.

Figure 3

Effects of ECE and DK on controlling lipid deposition and NAFLFD activity. (A and B) Triglycerides (A) and free fatty acids (B) in the liver were increased by HFD/saline and decreased by ECE or DK treatment. (C and D) The hepatic lipid deposition by ORO staining was increased by HFD/saline and decreased after treatment with ECE or DK. (E–H) The NAFLD activity was scored by H&E staining (upper row). Enlarged images (lower row) show hepatic steatosis conditions including steatosis (S; black arrows), inflammation (I; red arrows), and ballooning (B; yellow arrows) of liver (E). Quantified graphs showed that the hepatic steatosis score (F), lobular inflammation score (G), and ballooning score (H) were increased by HFD/saline and decreased after treatment with ECE or DK. Data are mean ± SD. p < 0.05, a–f; Same letters indicate nonsignificant differences between groups as determined by multiple comparison (Mann–Whitney U test). DK, dieckol; ECE, Ecklonia cava extract; HFD, high-fat diet; H&E, hematoxylin and eosin staining; ORO, oil red O staining; NFD, normal fat diet.