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. 2021 Jun 1;9(6):1196. doi: 10.3390/microorganisms9061196

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Dose–response curves demonstrating the antiviral activity of C11-6′ when pre-incubated with A(H1N1)pdm09 variants before infection in MDCK cells. OS p9 = virus passaged nine times in the presence of OS alone; λ p9 = virus passaged nine times in the presence of IFN λ1 alone; OS/λ p9 = virus passaged nine times in the presence of OS plus IFN λ1; UTR p9 = virus passaged nine times in the absence of selective drug pressure; N09 Stock = virus produced in MDCK cells and never passaged in Calu-3. Mean EC50 values and standard deviations were calculated from two independent experiments performed in duplicate.