Table 3.
Effect of Jasminum spp. against oxidative stress-related diseases.
| Botanical Name | Plant Part | Solvent/Dose | Activity | Model | Biomarkers Affected | References |
|---|---|---|---|---|---|---|
|
Jasminum grandiflorum L. |
F | E (300 mg/kg p.o.) | Chemo preventive | 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary carcinogenesis | ↑ vitamin E (plasma and erythrocytes) ↑ vitamin C (plasma) ↑reduced glutathione (plasma and erythrocytes) ↑ SOD, CAT (plasma, erythrocytes and mammary tissues) ↑ glutathione peroxidase (plasma, erythrocytes) ↓TBARS ↓ reduced glutathione (tissue) ↓glutathione peroxidase (tissue) |
[116] |
| L | M (100–800 μg/mL) | Anti-inflammatory | LPS (20 ng/mL)-induced nitric oxide in rat peritoneal macrophage | ↓ NO production (13.26 μ M/1 x 105 cells to 4.41 μM/1 x 105 cells) | [100] | |
| L | O | Wound healing | Cutaneous wound healing in diabetic rats | ↑ wound contraction ↑total hydroxyl proline, ↑ hexosamine ↑ protein ↑ DNA content ↑ Tensile strength ↑collagen & fibrous tissue ↑ number of blood vessels ↑SOD, CAT and GSH content ↓ lipid peroxidation |
[117] | |
|
Jasminum sambac (L.) Aiton |
R | E | Anti-inflammatory | Carrageenan-induced rat paw edema model and cotton pellet-induced granuloma in rats | ↓ paw edema ↓ granuloma formation ↓ AST, ALT, LPO, ↑ SOD and CAT |
[118] |
| F | LFE | Anti-aging | UVB (40 mJ/cm2 ) or H2O2 (200 μM) -induced HS68 dermal fibroblast cell | ↓ ROS production ↓ aging markers, such as p16, p21, and p53, ↓ MMP-1 ↓ SA-β-Gal -positive cells ↓ p-ERK, p-JNK, p-P38, and p-c-jun protein levels ↑ p-smad2/3 in the nuclear fraction ↑ TGFβ, p-smad2/3, COL1A1, and COL3A1 protein levels ↑ phoshpho-Nuclear respiratory factor 2 and antioxidant gene expression (HO-1) |
[119] |
F: Flower, R: Roots, L: Leaves, E: Ethanol, M: Methanol, BWE: a boiling water extract, HME: Hydromethanolic extract, LFE: Lactobacillus rhamnosus fermented extract, O: ointment, LPS: Lipopolysaccharide, UVB: Ultraviolet B, H2O2: Hydrogen peroxide, SOD: Superoxide Dismutase, CAT: Catalase, TBARS: Thiobarbituric acid reactive substances (lipid peroxidation), NO: Nitric Oxide, GSH: Glutathione, AST: Aspartate transaminase, ALT: Alanine transaminase, LPO: lipid peroxidation, ROS: Reactive Oxygen Species, MMP-1: Matrix metalloproteinase-1, SA-β-Gal: Senescence-associated beta-galactosidase; COL1A1: Collagen Type I Alpha 1; COL3A1: Collagen Type III Alpha 1, and TGF-β: Transforming growth factor-beta.