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(A)—The receptor of FSH has low affinity for APPL1, therefore, only high levels of FSH trigger APPL1 activation. APPL1 activates Akt and stimulates PI3K, leading to the production of PIP3. (B)—The LH receptor poorly stimulates the activity of the alpha subunit of the Gq proteins. Thus, high LH levels lead to the activation of PLC that catalyze the cleavage of PIP2, producing IP3.
