Table 2.
Overexpressed genes associated with triazole exposure in A. fumigatus from previous RT-qPCR and RNA-seq studies.
| Overexpressed Gene Name | Encoded Protein | Fold Change When Exposed to Itraconazole | Fold Change When Exposed to Voriconazole | References |
|---|---|---|---|---|
|
abcA-1
(AFUA_1G17440) |
ABC multidrug transporter | 7.1 | NA | [25] |
|
abcA-2
(AFUA_2G15130) |
~6.50 | NA | [25] | |
|
abcB
(AFUA_1G10390) |
~4.50 | ~5.00–13.00 | [25,38] | |
|
abcC
(AFUA_1G14330) |
~5.50 | ~5.00–>20.00 | [25,38] | |
|
abcD
(AFUA_6G03470) |
~4.50 | ~2.00–>20.00 | [25,38] | |
|
abcE
(AFUA_7G00480) |
~1.00 | ~2.00–>20.00 | [25,38] | |
|
atrF
(AFUA_6G04360) |
31.7 | NA | [25] | |
|
mdr1
(AFUA_5G06070) |
~5.00 | ~2.00–5.00 | [25,38] | |
|
mdr4
(AFUA_1G12690) |
~4.70 | NA | [25] | |
| AFUA_5G02260 | ABC multidrug transporter, putative | ~4.90 | NA | [25] |
| AFUA_2G11580 | MFS multidrug transporter, putative | 14.2 | NA | [25] |
|
mfs56
(AFUA_1G05010) |
~4.50–700.00 | NA | [25] | |
|
mfsA
(AFUA_8G05710) |
MFS multidrug transporter |
~4.70 | ~1.50–11.00 | [25,38] |
|
mfsB
(AFUA_1G15490) |
NA | ~4.00–18.00 | [38] | |
|
mfsC
(AFUA_1G03200) |
~7.90 | ~2.50–30.00 | [25,38] | |
|
cyp51A
(AFUA_4G06890) |
14-alpha sterol demethylase | 21.00–550.90 | NA | [25] |
|
fbpA
(AFUA_1G14050) |
F-box domain protein | NA | ~ >50.00–600.00 | [38] |
|
aaaA
(AFUA_7G06680) |
AAA-family ATPase, putative | NA | ~2.00–90.00 | [38] |
|
finA
(AFUA_8G05800) |
C6 zinc finger domain protein | NA | ~4.00–40.00 | [38] |
| AFUA_1G02870 | Transcription factor involved in oxidative stress response, putative | 2.48–2.61 | NA | [39] |
| AFUA_1G04140 | C6 finger domain protein, putative | 2.04–2.94 | NA | [39] |
| AFUA_6G01960 | 2.01–3.02 | NA | [39] | |
| AFUA_6G03430 | 2.78–2.93 | NA | [39] | |
|
fumR
(AFUA_8G00420) |
C6 zinc finger transcription factor | 4.00–4.70 | NA | [39] |
| AFUA_5G07510 | 2.39–3.50 | NA | [39] | |
| AFUA_3G09130 | C6 transcription factor, putative | 1.73–2.22 | NA | [39] |
| AFUA_8G07360 | 1.90–1.92 | NA | [39] | |
|
cpcA
(AFUA_4G12470) |
BZIP transcription factor | NA | >1.50–~5.50 | [38] |
| AFUA_1G16460 | BZIP transcription factor (LziP), putative | 1.75–2.12 | NA | [39] |
| AFUA_7G03910 | C2H2 zinc finger protein | 2.50–2.86 | NA | [39] |
|
ace1
(AFUA_3G08010) |
C2H2 zinc-finger transcription factor, putative | 1.66–2.32 | NA | [39] |
| AFUA_4G13600 | 2.30–2.71 | NA | [39] | |
|
zfpA
(AFUA_8G05010) |
NA | ~1.50–60.00 | [38] | |
| AFUA_2G01190 | Cu-dependent DNA-binding protein, putative | 1.30–2.10 | NA | [39] |
| AFUA_4G06170 | Predicted DNA-binding transcription factor | 3.79–3.89 | NA | [39] |
| AFUA_5G02655 | 2.75–3.84 | NA | [39] | |
|
ada
(AFUA_5G06350) |
DNA repair and transcription factor, putative | 1.23–2.05 | NA | [39] |