Table 3.
Top 20 significant SNPs obtained from the GWAS that were associated with itraconazole resistance, arranged based on their −log10(p-values) from the highest to lowest.
| Chromosome | Position (bp) | Change | −log10(p-value) | Gene ID | Annotation | Predicted Effect |
|---|---|---|---|---|---|---|
| 1 | 2,538,614 | A to C | 6.15 | AFUA_1G09780 | Stomatin family protein | Missense Variant (Asp418Ala) |
| 2 | 1,845,323 | C to T | 5.14 | AFUA_2G06330—AFUA_2G07340 | Ubiquitin C-terminal hydrolase, putative—COP9 subunit 3, putative | Intergenic Region |
| 2 | 1,899,353 | C to T | 4.58 | AFUA_2G07430—AFUA_2G07440 | DDHD domain protein—Thioesterase family protein | Intergenic Region |
| 3 | 2,408,041 | T to C | 4.29 | AFUA_3G09400—AFUA_3G09450 | MFS transporter (Hol1), putative—Alpha/beta fold family hydrolase, putative | Intergenic Region |
| 8 | 623,331 | G to T | 4.09 | AFUA_8G02330 | Endoglucanase, putative | Non-coding Transcript Variant |
| 4 | 3,737,973 | C to T | 3.66 | AFUA_4G14300—AFUA_4G14310 | Dynamin family GTPase, putative—APH domain-containing protein | Intergenic Region |
| 5 | 2,063,521 | C to A | 3.42 | AFUA_5G08150 | ABC bile acid transporter, putative | Missense Variant (His105Gln) |
| 5 | 2,069,483 | G to A | 3.23 | AFUA_5G08160—AFUA_5G08170 | Cyclin, putative— Autophagy-related protein 3 (Atg3) |
Intergenic Region |
| 3 | 1,953,910 | G to A | 3.14 | AFUA_3G07730—AFUA_3G07740 | Uncharacterized protein—Uncharacterized protein | Intergenic Region |
| 6 | 3,054,001 | C to G | 3.08 | AFUA_6G12145—AFUA_6G12150 | Uncharacterized protein—BZIP transcription factor (Atf7), putative | Intergenic Region |
| 3 | 1,266,358 | A to G | 3.08 | AFUA_3G04310—AFUA_3G05320 | SnoRNA binding protein, putative—C2H2 finger domain protein, putative | Intergenic Region |
| 5 | 2,069,698 | A to G | 3.03 | AFUA_5G08160—AFUA_5G08170 | Cyclin, putative— Autophagy-related protein 3 (Atg3) |
Intergenic Region |
| 2 | 1,781,938 | G to A | 2.99 | AFUA_2G06205—AFUA_2G06220 | Yippee family protein—Zinc knuckle domain protein | Intergenic Region |
| 6 | 1,353,971 | T to C | 2.98 | AFUA_6G06350—AFUA_6G06360 | Proteasome subunit alpha type 3, putative—Mating alpha-pheromone (PpgA) | Intergenic Region |
| 4 | 1,363,615 | T to C | 2.96 | AFUA_4G04820—AFUA_4G05830 | C-4 methyl sterol oxidase (Erg25), putative—Methylthioribose-1-phosphate isomerase (Mri1) | Intergenic Region |
| 8 | 635,137 | A to G | 2.94 | AFUA_8G02350 | Polyketide synthase, putative | Missense Variant (Thr1206Ala) |
| 3 | 2,316,978 | A to G | 2.91 | AFUA_3G09090 | RING finger domain protein | Missense Variant (Glu298Gly) |
| 6 | 2,508,121 | A to G | 2.91 | AFUA_6G10140—AFUA_6G10150 | C6 transcription factor, putative—Uncharacterized protein | Intergenic Region |
| 2 | 2,074,852 | A to C | 2.89 | AFUA_2G08060 | Involucrin repeat protein | Missense Variant (Lys779Thr) |
| 2 | 2,080,579 | T to C | 2.89 | AFUA_2G08060 | Involucrin repeat protein | Synonymous Variant (His2640His) |