Table 5.
Top 20 significant SNPs obtained from the second GWAS associated with itraconazole resistance, arranged based on their −log10(p-values) from the highest to lowest.
| Chromosome | Position (bp) | Change | −log10(p-Value) | Gene ID | Annotation | Predicted Effect |
|---|---|---|---|---|---|---|
| 1 | 2,538,614 | A to C | 5.37 | AFUA_1G09780 | Stomatin family protein | Missense Variant (Asp418Ala) |
| 2 | 1,845,323 | C to T | 4.14 | AFUA_2G06330-AFUA_2G07340 | Ubiquitin C-terminal hydrolase, putative—COP9 subunit 3, putative | Intergenic Region |
| 8 | 623,331 | G to T | 3.96 | AFUA_8G02330 | Endoglucanase, putative | Non-coding Transcript Variant |
| 2 | 1,899,353 | C to T | 3.91 | AFUA_2G07430-AFUA_2G07440 | DDHD domain protein—Thioesterase family protein | Intergenic Region |
| 4 | 3,737,973 | C to T | 3.69 | AFUA_4G14300-AFUA_4G14310 | Dynamin family GTPase, putative—APH domain-containing protein | Intergenic Region |
| 5 | 2,063,521 | C to A | 3.52 | AFUA_5G08150 | ABC bile acid transporter, putative | Missense Variant (His105Gln) |
| * 3 | 267,884 | T to G | 3.36 | AFUA_3G01140-AFUA_3G01150 | Uncharacterized protein—GPI anchored cell wall protein, putative | Intergenic Region |
| 5 | 2,069,483 | G to A | 3.27 | AFUA_5G08160-AFUA_5G08170 | Cyclin, putative— Autophagy-related protein 3 (Atg3) |
Intergenic Region |
| 5 | 2,069,698 | A to G | 3.13 | AFUA_5G08160-AFUA_5G08170 | Cyclin, putative— Autophagy-related protein 3 (Atg3) |
Intergenic Region |
| * 3 | 2,389,222 | G to A | 3.12 | AFUA_3G09400-AFUA_3G09450 | MFS transporter (Hol1), putative—Alpha/beta fold family hydrolase, putative | Intergenic Region |
| 6 | 3,054,001 | C to G | 2.99 | AFUA_6G12145-AFUA_6G12150 | Uncharacterized protein—BZIP transcription factor (Atf7), putative | Intergenic Region |
| * 3 | 2,414,011 | A to G | 2.87 | AFUA_3G09480 | 15-hydroxyprostaglandin dehydrogenase (NAD(+)) | Synonymous Variant (Ser60Ser) |
| 3 | 1,953,910 | G to A | 2.84 | AFUA_3G07730-AFUA_3G07740 | Uncharacterized protein—Uncharacterized protein | Intergenic Region |
| * 6 | 145,947 | T to C | 2.84 | AFUA_6G00570-AFUA_6G00580 | Uncharacterized protein—Ankyrin repeat protein | Intergenic Region |
| * 6 | 262,795 | G to A | 2.79 | AFUA_6G01860 | MFS lactose permease, putative | Missense Variant (Val106Met) |
| * 3 | 1,883,390 | C to A | 2.78 | AFUA_3G07510-AFUA_3G07520 | Uncharacterized protein— Exo-beta-1,3-glucanase, putative |
Intergenic Region |
| 3 | 2,316,978 | A to G | 2.77 | AFUA_3G09090 | RING finger domain protein | Missense Variant (Glu298Gly) |
| 3 | 1,266,358 | A to G | 2.76 | AFUA_3G04310-AFUA_3G05320 | SnoRNA binding protein, putative—C2H2 finger domain protein, putative | Intergenic Region |
| * 1 | 3,885,980 | G to A | 2.74 | AFUA_1G14540 | Oxidoreductase, short-chain dehydrogenase/reductase family | Non-coding Transcript Variant |
| * 6 | 734,136 | G to T | 2.72 | AFUA_6G03400-AFUA_6G03430 | Uncharacterized protein—C6 finger transcription factor (FsqA) | Intergenic Region |
Unique SNP sites are denoted by asterisks “*” (n = 8).