Table 7.
Top 20 significant SNPs obtained from the third GWAS associated with itraconazole resistance, arranged based on their −log10(p-values) from the highest to lowest.
| Chromosome | Position (bp) | Change | −log10(p-Value) | Gene ID | Annotation | Predicted Effect |
|---|---|---|---|---|---|---|
| 8 | 635,137 | A to G | 3.72 | AFUA_8G02350 | Polyketide synthase (PKS), putative | Missense Variant (Thr1206Ala) |
| 8 | 623,331 | G to T | 3.50 | AFUA_8G02330 | Endoglucanase, putative | Non-coding Transcript Variant |
| 5 | 2,069,698 | A to G | 3.26 | AFUA_5G08160-AFUA_5G08170 | Cyclin, putative—Autophagy-related protein 3 (Atg3) | Intergenic Region |
| * 5 | 419,750 | A to G | 3.11 | AFUA_5G01640-AFUA_5G01650 | Ankyrin repeat protein—bZIP transcription factor (JlbA), putative | Intergenic Region |
| 1 | 2,538,614 | A to C | 3.06 | AFUA_1G09780 | Stomatin family protein | Missense Variant (Asp418Ala) |
| * 8 | 629,524 | G to T | 3.01 | AFUA_8G02340-AFUA_8G02350 | Uncharacterized protein—Polyketide synthase, putative | Intergenic Region |
| * 8 | 576,158 | T to C | 2.96 | AFUA_8G02210-AFUA_8G02220 | Alpha-ketoglutarate-dependent taurine dioxygenase—Uncharacterized protein | Intergenic Region |
| * 5 | 2,131,740 | T to C | 2.94 | AFUA_5G08390 | Response regulator, putative (Ssk1) | Synonymous Variant (Lys532Lys) |
| 4 | 3,737,973 | C to T | 2.83 | AFUA_4G14300-AFUA_4G14310 | Dynamin family GTPase, putative—APH domain-containing protein | Intergenic Region |
| * 4 | 2,539,714 | C to A | 2.77 | AFUA_4G09770 | Velvet domain-containing protein | Synonymous Variant (Leu193Leu) |
| 1 | 3,885,980 | G to A | 2.74 | AFUA_1G14540 | Oxidoreductase, short-chain dehydrogenase/reductase family | Non-coding Transcript Variant |
| * 3 | 1,256,445 | T to A | 2.74 | AFUA_3G04310-AFUA_3G05320 | SnoRNA binding protein, putative— C2H2 finger domain protein, putative |
Intergenic Region |
| * 6 | 2,141,290 | T to C | 2.72 | AFUA_6G09000-AFUA_6G09010 | PHD finger domain protein, putative—U1 snRNP splicing complex subunit (Luc7), putative | Intergenic Region |
| 3 | 2,389,222 | G to A | 2.70 | AFUA_3G09400-AFUA_3G09450 | MFS transporter (Hol1), putative—Alpha/beta fold family hydrolase, putative | Intergenic Region |
| * 5 | 810,835 | T to C | 2.67 | AFUA_5G03020-AFUA_5G03030 | 6 0S ribosomal protein L4, putative— C6 transcription factor, putative |
Intergenic Region |
| * 6 | 2,891,637 | A to G | 2.65 | AFUA_6G11620-AFUA_6G11630 | Formyltetrahydrofolate deformylase, putative—FAD-dependent isoamyl alcohol oxidase, putative | Intergenic Region |
| 5 | 2,063,521 | C to A | 2.64 | AFUA_5G08150 | ABC bile acid transporter, putative | Missense Variant (His105Gln) |
| * 8 | 1,069,676 | A to G | 2.63 | AFUA_8G04680 | Oxidoreductase, short-chain dehydrogenase/reductase family, putative | Non-coding Transcript Variant |
| * 1 | 1,585,001 | C to T | 2.62 | AFUA_1G00410 | C6 transcription factor, putative | Intragenic Variant |
| * 4 | 3,891,318 | A to C | 2.59 | AFUA_4G14751-AFUA_4G14770 | Uncharacterized protein— Protostadienol synthase (HelA) |
Intergenic Region |
Unique SNP sites compared to the previous two GWAS analyses are denoted by asterisks “*” (n = 12).