Table 9.
Top 20 significant SNPs obtained from the fourth GWAS associated with itraconazole resistance, arranged based on their −log10(p-values) from the highest to lowest.
| Chromosome | Position (bp) | Change | −log10(p-Value) | Gene ID | Annotation | Predicted Effect |
|---|---|---|---|---|---|---|
| 1 | 2,538,614 | A to C | 4.86 | AFUA_1G09780 | Stomatin family protein | Missense Variant (Asp418Ala) |
| 2 | 1,845,323 | C to T | 3.21 | AFUA_2G06330—AFUA_2G07340 | Ubiquitin C-terminal hydrolase, putative—COP9 subunit 3, putative | Intergenic Region |
| 8 | 623,331 | G to T | 3.04 | AFUA_8G02330 | Endoglucanase, putative | Non-coding Transcript Variant |
| 2 | 1,899,353 | C to T | 3.03 | AFUA_2G07430—AFUA_2G07440 | DDHD domain protein—Thioesterase family protein | Intergenic Region |
| 5 | 2,063,521 | C to A | 2.91 | AFUA_5G08150 | ABC bile acid transporter, putative | Missense Variant (His105Gln) |
| 3 | 2,389,222 | G to A | 2.88 | AFUA_3G09400-AFUA_3G09450 | MFS transporter (Hol1), putative—Alpha/beta fold family hydrolase, putative | Intergenic Region |
| 5 | 2,069,483 | G to A | 2.76 | AFUA_5G08160—AFUA_5G08170 | Cyclin, putative— Autophagy-related protein 3 (Atg3) |
Intergenic Region |
| 6 | 3,054,001 | C to G | 2.76 | AFUA_6G12145—AFUA_6G12150 | Uncharacterized protein—BZIP transcription factor (Atf7), putative | Intergenic Region |
| 5 | 2,069,698 | A to G | 2.71 | AFUA_5G08160—AFUA_5G08170 | Cyclin, putative— Autophagy-related protein 3 (Atg3) |
Intergenic Region |
| 3 | 267,884 | T to G | 2.70 | AFUA_3G01140-AFUA_3G01150 | Uncharacterized protein—GPI anchored cell wall protein, putative | Intergenic Region |
| * 6 | 2,895,225 | T to C | 2.56 | AFUA_6G11620-AFUA_6G11630 | Formyltetrahydrofolate deformylase, putative—FAD-dependent isoamyl alcohol oxidase, putative | Intergenic Region |
| 3 | 1,953,910 | G to A | 2.54 | AFUA_3G07730—AFUA_3G07740 | Uncharacterized protein—Uncharacterized protein | Intergenic Region |
| 4 | 3,737,973 | C to T | 2.54 | AFUA_4G14300—AFUA_4G14310 | Dynamin family GTPase, putative—APH domain-containing protein | Intergenic Region |
| * 3 | 228,628 | C to T | 2.54 | AFUA_3G00970-AFUA_3G00980 | Uncharacterized protein—MFS transporter Liz1/Seo1, putative | Intergenic Region |
| * 5 | 2,042,856 | G to A | 2.53 | AFUA_5G08050-AFUA_5G08060 | Aminopeptidase P, putative—Importin 13, putative | Intergenic Region |
| *3 | 2,456,111 | A to G | 2.53 | AFUA_3G09630-AFUA_3G09640 | Asparaginyl-tRNA synthetase Slm5, putative—Camp independent regulatory protein | Intergenic Region |
| * 3 | 247,848 | G to A | 2.53 | AFUA_3G01060-AFUA_3G01070 | Uncharacterized protein—Tyrosinase, putative | Intergenic Region |
| * 3 | 220,452 | G to A | 2.52 | AFUA_3G00930 | C6 transcription factor, putative | Synonymous Variant (Ile259Ile) |
| 3 | 2,408,041 | T to C | 2.50 | AFUA_3G09400—AFUA_3G09450 | MFS transporter (Hol1), putative—Alpha/beta fold family hydrolase, putative | Intergenic Region |
| 3 | 2,414,011 | A to G | 2.48 | AFUA_3G09480 | 15-hydroxyprostaglandin dehydrogenase (NAD(+)) | Synonymous Variant (Ser60Ser) |
Unique SNP sites compared to the previous three GWAS analyses are denoted by asterisks “*” (n = 6).