Table 10.
Top 20 significant SNPs obtained from the fourth GWAS associated with voriconazole resistance, arranged based on their −log10(p-values) from the highest to lowest.
| Chromosome | Position (bp) | Change | −log10(p-Value) | Gene ID | Annotation | Predicted Effect |
|---|---|---|---|---|---|---|
| 8 | 613,458 | G to A | 3.82 | AFUA_8G02290-AFUA_8G02300 | Uncharacterized protein—FMN-dependent dehydrogenase family protein | Intergenic Region |
| 8 | 611,467 | C to A | 3.22 | AFUA_8G02280 | C6 transcription factor, putative | Missense Variant (Glu79Asp) |
| 3 | 246,050 | C to A | 2.93 | AFUA_3G01060-AFUA_3G01070 | Uncharacterized protein—Tyrosinase, putative | Intergenic Region |
| * 4 | 12,352 | G to A | 2.80 | Chr Start—AFUA_4G00100 | Rhamnogalacturonase, putative | Intergenic Region |
| * 8 | 641,537 | T to C | 2.79 | AFUA_8G02380-AFUA_8G02390 | FAD-dependent monooxygenase, putative—Uncharacterized protein | Intergenic Region |
| 4 | 2,539,714 | C to A | 2.75 | AFUA_4G09770 | Velvet domain-containing protein | Synonymous Variant (Leu193Leu) |
| * 8 | 331,435 | C to A | 2.62 | AFUA_8G01340 | MFS sugar transporter, putative | Missense Variant (Leu239Met) |
| * 5 | 295,677 | C to T | 2.62 | AFUA_5G01180 | RAN small monomeric GTPase (Ran), putative | Synonymous Variant(Ser74Ser) |
| * 5 | 256,650 | T to C | 2.61 | AFUA_5G01000 | Oxidoreductase, 2OG-Fe(II) oxygenase family, putative | Missense Variant (Ser110Pro) |
| * 2 | 417,623 | C to T | 2.60 | AFUA_2G01700 | Carbon catabolite derepressing protein kinase (Snf1), putative | Missense Variant (Arg188Gln) |
| 2 | 426,803 | C to T | 2.59 | AFUA_2G01740 | Sulfate transporter, putative | Synonymous Variant (Ala141Ala) |
| * 8 | 503,790 | C to G | 2.59 | AFUA_8G01940 | C6 finger domain protein, putative | Missense Variant (Pro261Arg) |
| 2 | 420,712 | T to C | 2.55 | AFUA_2G01710 | GPI anchored protein, putative | Synonymous Variant (Ile294Ile) |
| * 1 | 1,138,713 | A to G | 2.53 | AFUA_1G00410 | C6 transcription factor, putative | Intragenic Variant |
| 2 | 441,695 | C to T | 2.53 | AFUA_2G01780 | Small nucleolar ribonucleoprotein complex subunit (Utp15), putative | Synonymous Variant (Val184Val) |
| * 5 | 3,788,892 | C to T | 2.53 | AFUA_5G14610 | Carboxypeptidase Y, putative | Missense Variant (Val254Met) |
| * 5 | 1,815,994 | A to G | 2.50 | AFUA_5G07300- AFUA_5G07310 | Electron transfer flavoprotein, beta subunit—DUF500 domain protein | Intergenic Region |
| * 1 | 3,306,670 | A to C | 2.50 | AFUA_1G12540 | TMEM1 family protein, putative | Missense Variant (Phe879Cys) |
| * 4 | 1,285,247 | G to A | 2.50 | AFUA_4G04570 | Uncharacterized protein | Non-coding Transcript Variant |
| 8 | 388,274 | G to A | 2.50 | AFUA_8G01510-AFUA_8G01520 | Uncharacterized protein—Pectinesterase | Intergenic Region |
Unique SNP sites compared to the previous three GWAS analyses are denoted by asterisks “*” (n = 12).