Table 12.
Additional non-synonymous SNPs found to be highly linked to the 62 SNP sites obtained by GWAS analyses for voriconazole.
| Chromosome | Position | Gene ID | Predicted Effect (Amino Acid Substitution) |
Description |
|---|---|---|---|---|
| 1 | 976,070 | AFUA_1G03370 | Missense Variant (Ser226Leu) | Uncharacterized protein |
| 1 | 4,754,138 | AFUA_1G17380 | Missense Variant (Leu226Pro) | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative |
| 2 | 437,241 | AFUA_2G01760 | Missense Variant (Thr1812Ala) | NACHT domain protein |
| 2 | 541,777 | AFUA_2G02170 | Missense Variant (Ser67Pro) | Nuclear condensin complex subunit (Smc4), putative |
| 5 | 205,924 | AFUA_5G00730 | Missense Variant (Val814Phe) | H /K ATPase alpha subunit, putative |
| 5 | 3,290,025 | AFUA_5G12670 | Missense Variant (Phe390Ser) | Nucleoporin (Nup192), putative |
| 6 | 3,252,789 | AFUA_6G12890 | Missense Variant (Arg878Gly) | Vacuole-associated enzyme activator complex component (Vac14), putative |
| 6 | 3,330,314 | AFUA_6G13180 | Missense Variant (Ala529Thr) | CECR1 family adenosine deaminase, putative |
| 7 | 1,457,904 | AFUA_7G05960 | Missense Variant (Arg1037Gln) | C2H2 finger domain protein, putative |
| 7 | 1,541,519 | AFUA_7G06290 | Missense Variant (Gln666Leu) | NACHT domain protein, putative |
| 8 | 332,292 | AFUA_8G01340 | Missense Variant (Met524Ile) | MFS sugar transporter, putative |