Table 13.
Highly linked significant SNP sites associated with triazole resistance determined using Fisher’s Exact tests (n = 122).
| Chromosome | Position (bp) | Gene ID | Predicted Effect (Amino Acid Substitution) |
Fisher’s Exact Test (p-Values), MIC ≥ 2 mg/L | Fisher’s Exact Test (p-Values), MIC ≥ 4 mg/L | ||
|---|---|---|---|---|---|---|---|
| Itraconazole | Pan-Azole | Itraconazole | Pan-Azole | ||||
| 1 | 976,070 | AFUA_1G03370 | Missense Variant (Ser226Leu) | 2.37 × 10−5 * | 8.10 × 10−6 * | 2.37 × 10−5 * | 5.48 × 10−6 * |
| 1 | 4,754,138 | AFUA_1G17380 | Missense Variant (Leu226Pro) | 8.40 × 10−6 * | 5.57 × 10−5 * | 8.40 × 10−6 * | 9.21 × 10−5 * |
| 3 | 2,304,691 | AFUA_3G09040 | Missense Variant (Ser13Leu) | 3.92 × 10−4 * | 3.82 × 10−3 | 3.92 × 10−4 * | 2.41 × 10−3 |
| 3 | 2,311,362 | AFUA_3G09070 | Missense Variant (Ile406Thr) | 3.74 × 10−4 * | 1.99 × 10−3 | 3.74 × 10−4 * | 2.41 × 10−3 |
| 3 | 2,409,306 | AFUA_3G09450 | Missense Variant (Pro220Leu) | 2.79 × 10−4 * | 7.05 × 10−5 * | 2.79 × 10−4 * | 1.64 × 10−4 * |
* Statistically significant association between SNP and antifungal resistance.