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. 2021 Jun 8;13(6):854. doi: 10.3390/pharmaceutics13060854

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 2 — Transformation of HA to preactivated thiol-bearing HA (Reaction 6 from Figure 9) for its later crosslinking with the macro-crosslinker PEG-dithiol [138].