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. 2021 Jun 9;10(6):937. doi: 10.3390/antiox10060937

Figure 1.

Figure 1

Effects of limonene on mitochondrial dehydrogenase activity in NGF-differentiated PC12 cells and primary cortical neurons exposed to Aβ1-42 oligomers. (A) Evaluation of the mitochondrial dehydrogenase activity by MTT assay in NGF-differentiated PC12 cells exposed to limonene at different concentrations (5, 10, and 25 µg/mL) for 24 h. (B,C) Quantification of mitochondrial dehydrogenase activity assessed by MTT assay in NGF-differentiated PC12 cells (B) and primary cortical neurons (C) exposed to Aβ1-42 oligomers (5 µM/24 h) in the presence and in absence of limonene (10 µg/mL, 30 min pre-treatment). Data are shown as percentage of mitochondrial dehydrogenase activity (compared to control cells) and values are expressed as mean ± SEM of three independent experimental sessions (* p < 0.05 vs control; ** p < 0.05 vs. Aβ1-42).