Figure 6.

Biological functions of the p53/p73 family isoforms in colorectal cancer. The p53 and p73 isoforms have been implicated in many biological roles in colorectal cancer, namely, drug resistance, proliferation, autophagy, inflammation, stemness, metabolism, DNA repair, angiogenesis, and invasion. Here, the functions are organized in a circular fashion with isoforms associated with a certain biological role listed next to the roles. See Table 1 for details on molecular pathways and references.