. 2021 May 31;10(6):884. doi: 10.3390/antiox10060884

Table 1.

Effects of the supplementation of the maternal diet without (Ctrl) or with HTX on the mean values of the concentration of neurotransmitters in the amygdala of 100-day fetuses and 1-month- and 6-month-old pigs.

		Fetuses	1 Month	6 Months	p-Values
		Fetuses	1 Month	6 Months	Treatment	Age	Interaction
NA	Ctrl	44.00 ± 2.42 ^Aa	107.93 ± 15.13 ^Ab	106.33 ± 5.65 ^Ab	0.143	<0.001	<0.001
NA	HTX	31.46 ± 1.84 ^Ba	126.21 ± 9.21 ^Ab	160.86 ± 18.45 ^Bb	0.143	<0.001	<0.001
DA	Ctrl	204.36 ± 12.56 ^Aa	496.22 ± 56.40 ^Ab	294.06 ± 36.78 ^Ac	0.062	<0.001	0.032
DA	HTX	309.88 ± 32.97 ^Ba	404.25 ± 26.16 ^Ab	406.63 ± 56.90 ^Bab	0.062	<0.001	0.032
DOPAC	Ctrl	94.84 ± 4.28 ^Aa	133.03 ± 15.14 ^Ab	114.31 ± 6.48 ^Aab	<0.001	0.008	0.072
DOPAC	HTX	143.09 ± 7.00 ^Ba	162.14 ± 13.17 ^Aa	139.50 ± 15.03 ^Aa	<0.001	0.008	0.072
HVA	Ctrl	294.93 ± 13.26 ^Aa	301.14 ± 43.09 ^Aa	270.65 ± 18.18 ^Aa	0.002	<0.001	0.001
HVA	HTX	432.63 ± 14.85 ^Ba	270.08 ± 19.39 ^Ab	345.39 ± 40.52 ^Ab	0.002	<0.001	0.001
DOPAC/DA	Ctrl	0.51 ± 0.02 ^Aa	0.28 ± 0.02 ^Ab	0.46 ± 0.03 ^Aa	0.082	<0.001	0.008
DOPAC/DA	HTX	0.70 ± 0.17 ^Aa	0.41 ± 0.02 ^Bb	0.39 ± 0.03 ^Ab	0.082	<0.001	0.008
HVA/DA	Ctrl	1.62 ± 0.09	0.63 ± 0.04	1.08 ± 0.07	0.763	<0.001	0.429
HVA/DA	HTX	2.23 ± 0.43	0.70 ± 0.04	0.98 ± 0.08	0.763	<0.001	0.429
(DOPAC + HVA)/DA	Ctrl	2.14 ± 0.11	0.91 ± 0.06	1.54 ± 0.09	0.422	<0.001	0.206
(DOPAC + HVA)/DA	HTX	2.93 ± 0.59	1.11 ± 0.06	1.37 ± 0.11	0.422	<0.001	0.206
DOP total	Ctrl	594.13 ± 26.24 ^Aa	930.39 ± 106.55 ^Ab	679.01 ± 59.47 ^Aa	0.001	0.034	0.002
DOP total	HTX	885.61 ± 46.65 ^Ba	836.47 ± 50.81 ^Aa	891.51 ± 103.69 ^Ba	0.001	0.034	0.002
5-HT	Ctrl	312.30 ± 14.32	731.64 ± 43.08	894.76 ± 41.52	<0.001	<0.001	0.111
5-HT	HTX	417.39 ± 17.59	886.94 ± 46.18	998.98 ± 95.43	<0.001	<0.001	0.111
5-HIAA	Ctrl	113.45 ± 5.28 ^Aa	169.36 ± 8.33 ^Ab	184.00 ± 7.19 ^Ab	0.008	<0.001	<0.001
5-HIAA	HTX	163.29 ± 5.73 ^Ba	196.31 ± 12.09 ^Aa	183.75 ± 18.56 ^Aa	0.008	<0.001	<0.001
5-HIAA/5-HT	Ctrl	0.39 ± 0.02	0.24 ± 0.01	0.21 ± 0.01	0.321	<0.001	0.059
5-HIAA/5-HT	HTX	0.41 ± 0.02	0.23 ± 0.02	0.18 ± 0.01	0.321	<0.001	0.059
IND total	Ctrl	425.75 ± 17.86 ^Aa	901.00 ± 48.81 ^Ab	1078.76 ± 45.48 ^Ab	<0.001	<0.001	0.021
IND total	HTX	580.68 ± 21.36 ^Ba	1083.25 ± 51.18 ^Bb	1182.73 ± 111.92 ^Ab	<0.001	<0.001	0.021

Concentrations are presented as the mean ± SE. Units ng/g tissue. Different capital letters (Aa = Ab = Ac = Aab) ≠ (Ba = Bb = Bab) represent significant differences between treatments for each age (p < 0.05). Different lowercase letters (Aa = Ba = Aab = Bab) ≠ (Ab = Bb = Aab = Bab) ≠ Ac represent significant differences between ages for the same treatment (p < 0.05). NA: noradrenalin; DA: dopamine; DOPAC: 3,4-dihydroxyphenyl acetic acid; HVA: homovanillic acid; 5-HT: serotonin/5-hydroxytryptamine; 5-HIAA: 5-hydroxyindoleacetic acid; DOP total: total dopaminergic neurotransmitters; IND total: total serotoninergic neurotransmitters.