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. 2021 Jun 9;22(12):6236. doi: 10.3390/ijms22126236

Figure 2.

Figure 2

ACAT inhibitor does not prevent TNFα-induced LDL cholesterol accumulation. Cells in serum-free medium were treated with 0 or 100 ng/mL TNFα in the presence of 0.1% DMSO (DMSO) or 10 µg/mL ACAT inhibitor (Sandoz 58-035) and 100 µg/mL LDL for 24 hrs. After washing with heparin as described under Materials and Methods, the cellular cholesterol content was determined. (A) unesterified cholesterol, (B) esterified cholesterol, and (C) total cholesterol. n = 3. *, **, ***, p < 0.05, 0.01, 0.001, relative to corresponding Ctrl or as indicated with bars.