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HMGA1 is expressed in the nuclei of trophoblasts. (A,C) HMGA1 is expressed only in the nuclei of EVTs derived from human normal placenta and at the implantation site of normal pregnant mouse. (B,D) HMGA1 in cytoplasm is observed in human PE placenta and HMGA1 is also extracellularly released from trophoblasts derived from our PE model. Scal bar = 100um. (This figure is quoted and modified from Ref [75]).
