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Map of the genome of HBV with overlapping and non-overlapping coding regions. Pre-S1, Pre-S2, and S are the domains of surface protein. TP, SP, RT, and RNase are the domains of polymerase. TP, terminal protein domain; SP, spacer domain; RT, reverse transcriptase domain; RNase, ribonuclease domain; C, capsid. Figure reproduced from [100] with the permission of the Microbiology Society.
