Table 1.

β-CoV inhibitors target N protein.

Compounds	Target Domain or Process	Mechanism	Reference
PJ34, N-(6-oxo-5,6-dihydrophenanthridin-2-yl) (N,N-dimethylamino) acetamide hydrochloride	NTD	Reduce RNA binding	[14,67]
H3, 6-chloro-7-(2-morpholin-4-ylethylamino) quinoxaline-5,8-dione	NTD	Reduce RNA binding	[61]
(−)-catechin gallate	NTD	Reduce RNA binding	[66]
(−)-gallocatechin gallate	NTD	Reduce RNA binding	[66]
P3, 5-benzyloxygr- amine	CTD	Induce abnormal dimerization	[62]
1,6-hexanediol	LLPS	prevent condensate formation	[68]
Lipoic acid	LLPS	Reduce smaller condensate	[68,69]