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. 2021 Jun 8;13(6):853. doi: 10.3390/pharmaceutics13060853

Figure 3.

Figure 3

(A) Schematic of GSH responsive human serum albumin (HSA) nanocarrier for chemo-photothermal therapy. HSA nanoparticles were synthesized using the reduction-reassembly method. HSA molecules were reduced using excessive GSH to expose a large amount of reactive sulfhydryl groups. ICG and DOX were encapsulated in HSA nanoparticles. HSA nanoparticles were formed due to formation of new formed disulfide bond during the solvent removal process. (B) NIR radiation was used for photothermal ablation of tumor cells. Moreover, NIR-mediated slight hyperthermia was used for promoting the cellular uptake of HSA nanoparticles to amplify the therapeutic efficacy of DOX. (C) DOX release profile from different groups in presence or absence of GSH. (D) Temperature change in response to NIR irradiation. (E) Tumor growth curve of 4T1 tumor-bearing mice in different treatment groups. Adapted with permission from [157]. *** p < 0.001. Copyright 2020 American Chemical Society.