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. 2021 Mar 25;121(12):6744–6776. doi: 10.1021/acs.chemrev.0c01076

Table 4. Stereochemistry of Reaction Products between Protected Cysteine and Various Electrophilic Alkynes in pH Buffer and Aqueous Acetonitrile67.

2.2.1.

    E/Z
R1 R2 H2O pH = 8 buffer
–NHPh H 20/80 5/95
–OMe H 66/34 11/89
–Ph H 25/75 17/83
–CH2CH2Ph H 34/66 34/66
–Ph –C4H9 20/80 34/66
–CH2CH2Ph –C4H9 66/34 34/66