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. 2021 Jun 9;13(12):2891. doi: 10.3390/cancers13122891
CXCR-4 C-X-C chemokine receptor type 4
CCR7 C-C chemokine receptor type 7
CXCL12/SDF-1α stromal cell-derived factor 1
CCL21/6Ckine C-C chemokine ligand 21
BBB blood–brain barrier
SSP serine synthesis pathway
BEF brain extracellular fluid
SGOC serine and glycine one carbon metabolism
PHGDH phosphoglycerate dehydrogenase
GlyR strychnine-sensitive glycine receptor
GlyT1 glycine transporter 1
GlyT2 glycine transporter 2
NMDR N-methyl-D-aspartate receptors
GABA gamma-aminobutyric acid
SHMT2 serine hydroxymethyltransferase 2
MTHFD2 methylenetetrahydrofolate dehydrogenase 2
MTHFD1L methylenetetrahydrofolate dehydrogenase 1L
PSAT phosphoserine aminotransferase
PSP phosphoserine phosphatase
GSH glutathione
ROS reactive oxygen species
PDAC pancreatic ductal adenocarcinoma
mGluRs metabotropic glutamate receptors
SLC1A4 solute carrier 1A4
SLC1A5 solute carrier 1A5
EAAT excitatory amino acid transporter
SNAT3 sodium neutral amino acid transporter 3
THF tetrahydrofolate
SHMT1 serine hydroxymethyltransferase 1
NADPH nicotinamide adenine dinucleotide phosphate
TCA tricarboxylic acid cycle