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The current model of JMJ-mediated balance between H3K27me3 and H3K4me3 at the HSP21 locus. Three red and green circles represent H3K27me3 and H3K4me3, respectively. JMJs are required to sustain H3K4me3 methylation. In jmjq mutants, higher H3K27me3 accumulation inhibits proper accumulation of H3K4me3 at the HSP21 locus.
