Figure 6.

The study was designed to assess cardiac function and contractile reserve following an experimental murine model of the ligation of the left coronary artery without reperfusion in mice consuming an OLT1177-enriched diet. (1) Three days after MI surgery, all of the mice underwent transthoracic echocardiography and were randomly assigned into four groups. (2) After their recovery from the surgery, the four groups of mice were administered either a standard diet or an OLT1177-enriched diet (3.75 g/kg or 7.50 g/kg). (3) Seventy days post-MI, the effects of OLT1177 on cardiac function and contractile reserve were assessed via echocardiography and isoproterenol challenge. (4) About 2–3 days after the 10-week echocardiography and contractile reserve assessments, the diastolic function of all of the surviving mice was assessed via LV catheterization. Abbreviations: LAD = left anterior descending coronary artery; AMI = acute myocardial infarction; SD = standard diet; LV = left ventricular.