Table 2.

Proposed PODXL mechanisms in cancer metastasis.

Mechanism	Proteins That PODXL Interacts with	Cancer Type
EMT	Colocalisation and interaction with collagen I, interaction with ezrin, E-cadherin, and vimentin	Lung [63,81]
Migration and Invasion	Colocalisation and interaction with gelsolin	Pancreatic [73]
	Binding to ezrin	Breast [13]
	Enhancing the activation of PI3K, Ras/rac1, and MAPK signalling pathway	Pancreatic [18]
	Activation of rac1/cdc42/cortactin signalling	Breast [82]
	Activation of FAK	Oral squamous cell [83]
	Increasing MMP	Breast [13]
	Binding to selectins (E- and L-)	Colon [84]Pancreatic [66]
	Colocalisation and interaction with CLIC5	Liver [54]
	Binding to dynamin-2	Pancreatic [18]
	Stimulating the C5aR/C5a axis	Pancreatic [85]
	Associates with TAZ	Colon [86]
Extravasation from the vasculature	Binding to ezrin	Breast [87]
Immune evasion	Inhibiting NK cell receptors Increasing the expression of MHC I molecule (HLA-ABC)	Breast [17]
Chemoresistance	Increasing Bmi1	Oral tongue squamous cell [88]