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. 2021 May 26;13(6):1813. doi: 10.3390/nu13061813

Table 3.

Changes (Δ) in fasting insulin, glucagon, and area under the curve (AUC) from the Oral Glucose Tolerance Test regarding insulin (240 min), glucagon (240 min), and HOMA-IR calculations.

Experimental Diets
Control Mild and Sweet Bitter and Strong between Groups
Changes a p-Value b Changes a p-Value b Changes a p-Value b p-Value c
Fasting insulin (pmol/L) −1.99 ± 4.1 0.63 −7.77 ± 2.8 <0.01 −9.0 ± 3.33 <0.05 0.29
Fasting glucagon (pg/mL) −2.25 ± 2.19 0.32 −2.23 ± 1.73 0.21 −2.17 ± 1.78 0.28 0.99
AUC insulin240 min, (pmol/L ∗ 240 min) −632.7 ± 3355 0.85 −2795 ± 2777 0.32 −7199 ± 3476 < 0.05 0.21
AUC glucagon240 min (pg/mL ∗ 240 min) 142.7 ± 561.3 0.80 −159.5 ± 416.2 0.71 −13.6 ± 524.3 0.98 0.92
HOMA-IR −0.13 ± 0.42 0.76 −0.46 ± 0.23 0.06 −1.05 ± 0.23 <0.0001 0.057

a Data are presented as mean ± SEM. b Statistical calculations are within-group differences (paired t-test). c Statistical calculations are between group differences (ANOVA). † denotes use of non-normally distributed data and use of the Kruskal–Wallis test.