Figure 4.

Predicted Ca${}^{2+}$ transient amplitude and cell strain dependence on gel stiffness. (A) Shows the time evolution of CaT for values of K indicated in the legend. (B) Time evolution of cell strain starting at a value of ${ϵ}_0=0.05$. Curve labels as in (A). (C) Gel stiffness dependence of steady state values of CaT for different MCT amplifications set by values of $\overline{C}$ given in the legend of panel (D). (D) Similar to panel (C) but cell strains are shown. Simulation parameters: $K_{\infty }=5,K_c=0.5,K_g=1.2$, ${ϵ}_0=0.05,\overline{C}=5$ (except as noted), $\delta =0.1$, ${\alpha }_0=1,n_c=2,C_0=0.25$.