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. 2021 May 29;11(6):503. doi: 10.3390/life11060503

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Positive feedback is inherent in the model. (A) Closed loop structure of model. (B) Effect of loop structure on myocyte and mechanosensor strains. $ξ$ = surface mechanosensor strain, $ϵ$ = cell strain, C, ${Ca}^{2 +}$ transient amplitude, and K, gel stiffness.